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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually focused on the practical aspects of research design, like recruitment and consent as well as adherence to the use of standard equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and helps to reduce bias in the results. However, too much heterogeneity could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically commissioned by policymakers and 프라그마틱 슬롯버프 (Https://postheaven.Net) practitioners to inform their decisions. They are also a good way to identify the causality between an intervention and its outcomes. They should not, however, be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of studies were conducted in primary-care settings.